Estas son todas las misiones y pruebas de la guía, en un orden de juego válido. A menudo tendrás varias misiones disponibles a la vez: puedes alternar entre personajes, pero las últimas de cada uno exigen haber completado las anteriores (y a veces las de otros personajes).
Los Santos
- In the Beginning (prólogo)
- Big Smoke
- Ryder
- Tagging Up Turf
- Cleaning the Hood
- Drive-Thru
- Nines and AK's
- Drive-By
- Sweet's Girl
- Cesar Vialpando
- OG Loc
- Running Dog
- Wrong Side of the Tracks
- Just Business
- Home Invasion
- Catalyst
- Robbing Uncle Sam
- Life's a Beach
- Madd Dogg's Rhymes
- Management Issues
- Burning Desire
- Gray Imports
- Doberman
- Los Sepulcros
- House Party
- High Stakes, Low-Rider
- Reuniting the Families
- The Green Sabre
- Desafíos: Chiliad, BMX, tiro, 8-Track y triatlón
El campo
- Badlands
- First Date
- Tanker Commander
- First Base
- Against All Odds
- Gone Courting
- Small Town Bank
- Made in Heaven
- Local Liquor Store
- King in Exile
- Body Harvest
- Wu Zi Mu
- Farewell, My Love
- Are You Going to San Fierro?
San Fierro
- Wear Flowers in Your Hair
- 555 We Tip
- Deconstruction
- Autoescuela (Back to School)
- Air Raid
- Supply Lines...
- New Model Army
- Photo Opportunity
- Jizzy
- T-Bone Mendez
- Mike Toreno
- Outrider
- Snail Trail
- Ice Cold Killa
- Pier 69
- Toreno's Last Flight
- Mountain Cloud Boys
- Ran Fa Li
- Lure
- Amphibious Assault
- The Da Nang Thang
- Yay Ka-Boom-Boom
- Zeroing In
- Test Drive
- Customs Fast Track
- Puncture Wounds
- Desafío NRG-500
El desierto
- Monster
- Highjack
- Interdiction
- Verdant Meadows
- Escuela de vuelo (Learning to Fly)
- N.O.E.
- Stowaway
- Black Project
- Green Goo
- Escuela náutica (Boat School)
Las Venturas
- Fender Ketchup
- Explosive Situation
- You've Had Your Chips
- Don Peyote
- Intensive Care
- The Meat Business
- Fish in a Barrel
- Madd Dogg
- Freefall
- Saint Mark's Bistro
- Misappropriation
- High Noon
- Architectural Espionage
- Key to Her Heart
- Dam and Blast
- Cop Wheels
- Up, Up and Away!
- Breaking the Bank at Caligula's
- A Home in the Hills
- Escuela de motos (Bike School)
- Las misiones de la cantera